Senior Director, Pipeline Commercial Strategy

About   Iovance Biotherapeutics, Inc.

Iovance Biotherapeutics, Inc.  is the global leader in innovating, developing, and delivering tumor infiltrating lymphocyte (TIL) cell therapies for patients with solid tumors. Amtagvi® (lifileucel) is the first FDA-approved, one-time treatment for previously treated advanced melanoma, now approved in three global markets and available at more than 95 authorized treatment centers. The  Iovance TIL platform  spans registrational trials and next-generation programs in additional solid tumors, including gene-edited and IL-12 tethered TIL therapies, next-generation IL-2, and precision immuno-oncology approaches. As the first and only company to take TIL therapy from concept to a broadly accessible commercial treatment, Iovance operates as an end-to-end cell therapy company, anchored by fully owned, centralized U.S.-based manufacturing that is scaled to serve thousands of cancer patients worldwide each year. For more information, please visit  www.iovance.com.

Amtagvi® and its accompanying design marks, Proleukin ®, Iovance ®, and IovanceCares™ are trademarks and registered trademarks of Iovance Biotherapeutics, Inc. or its subsidiaries. All other trademarks and registered trademarks are the property of their respective owners.

Information on Iovance’s broad, industry-leading patent portfolio is available on the Intellectual Property page on  www.iovance.com.

Overview

The Sr. Director, Pipeline Commercial Strategy will own the commercial assessment of Iovance's pipeline assets, including market sizing, target product profiles and competitive analysis. This role brings deep commercial domain expertise to quantify market opportunities, shape portfolio and indication strategy, and ensure disciplined execution of priority workstreams from early, upstream pipeline development. This commercial subject matter expert will proactively identify what needs to be done, define the path forward, and drive the organization to execute.

Essential Functions and Responsibilities

• Senior commercial strategy role owning the commercial assessment of pipeline assets and indication expansions including market sizing and addressable market analysis, target product profiles (TPPs), competitive analysis, and representing reimbursement market analysis from early development through launch
• Defines and drives actionable commercial strategies, workplans, timelines, and readiness deliverables grounded in deep knowledge of oncology markets, treatment paradigms, and cell therapy commercialization
• Represents Commercial in established enterprise forums such as PDT and GDT, operating as the strategic integrator who drives alignment through expertise

New Product Planning & Portfolio Strategy

• Build market sizing and addressable market analyses by tumor type, line of therapy, and geography, using epidemiology, treatment-flow, and claims data to quantify the commercial opportunity
• Develop and maintain commercially grounded target product profiles (TPPs) for pipeline assets, defining the efficacy, safety, dosing, and differentiation thresholds needed to compete in each target indication
• Own competitive analysis and scenario planning for pipeline indications, tracking competitor programs, data readouts, and approvals, modeling competitive entry, label variation, treatment landscape shifts, and outpatient usage opportunities, and defining the differentiation strategy for Iovance assets
• Drive portfolio prioritization, forecasting, and commercial recommendations to inform Go/No-Go decisions for registrational trials
• Lead early commercial assessments for pipeline assets, indication expansions, in-licensing opportunities, acquisitions, and business development evaluations, applying deep market knowledge to shape investment decisions
• Provide commercial input on tumor target, indication, and launch market selection, including signal-finding studies and investigator-sponsored trials (ISTs) that support future registrational trials
• Partner with Clinical Development and project teams to influence clinical milestones, trial design assumptions, accelerated or regular approval pathways, and regional commercialization considerations based on commercial viability and market dynamics
• Own launch trackers, readiness scorecards, risk registers, and milestone dashboards as strategic tools using them to anticipate issues and drive proactive decision-making, not simply report status
• Must adhere to Iovance Biotherapeutics’ core values, policies, procedures, and business ethics
• Perform miscellaneous duties as assigned

Required Education, Skills, and Knowledge

• Bachelor's degree required; advanced degree such as MBA, MPH, PharmD, PhD, or relevant graduate degree preferred
• Typically 10+ years (Sr. Director/Director) of biopharmaceutical, biotech, oncology, cell therapy, specialty medicine, commercial strategy, launch planning, brand strategy, market access, consulting, or related experience
• Hands-on experience building market sizing and addressable market models, target product profiles, competitive assessments, and reimbursement or payer analyses for oncology or cell therapy assets
• Deep commercial domain expertise, this role requires someone who has personally shaped commercial strategy and made market-facing decisions, not solely managed timelines or coordinated workstreams
• Demonstrated ability to lead complex cross-functional initiatives, develop strategic recommendations grounded in data, and influence senior stakeholders through expertise and credibility
• Track record of leading product launches, new product planning, commercial assessments, forecasting, portfolio strategy, or launch readiness, as a strategic driver, not a project manager
• Strong executive presence, written communication, analytical thinking, and ability to influence without authority in a matrixed environment

Physical Demands and Activities Required

The physical demands described here represent those an employee may encounter while performing the essential functions of this job. Reasonable accommodation may be provided to enable individuals to perform these functions.

• Ability to remain in a stationary position for extended periods
• Ability to move about within an office or remote workspace and exert up to 10 pounds of force occasionally
• Visual acuity sufficient for preparing and analyzing data, viewing computer screens, and extensive reading
• Repetitive motion involving wrists, hands, and/or fingers
• Ability to communicate effectively to exchange information
• Ability to engage in analytical, conceptual, and problem‑solving activities in a dynamic business environment

Mental: Clear and conceptual thinking ability; excellent judgment, troubleshooting, problem-solving, analysis, and discretion; ability to handle work-related stress; ability to handle multiple priorities simultaneously with a sense of urgency; and ability to meet deadlines

Work Environment

This job operates in a professional or remote office environment and requires operating standard office equipment and keyboards.

#li-remote

The annual base salary we reasonably expect to pay is listed. Individual pay decisions depend on various factors, such as primary work location, complexity and responsibility of the role, job duties/requirements, and relevant education, experience and skills.

Pay Transparency

$270,000 — $290,000 USD

The statements contained in this document are intended to describe the general nature and level of work being performed by a colleague assigned to this description. They are not intended to constitute a comprehensive list of functions, duties, or local variances. Management retains the discretion to add or to change the duties of the position at any time.

Iovance is committed to cultivating and offering a diverse and inclusive work environment. As an equal-opportunity employer, our employees and applicants will be considered without regard to an individual’s race, color, religion, sex, pregnancy, national origin, age, physical and mental disability, marital status, sexual orientation, gender identity, gender expression, genetic information, military and veteran status, and any other characteristic protected by applicable law. If you need assistance or accommodation to apply to one of our opportunities, please contact [email protected].

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